Healthcare · HIPAA Compliant

HIPAA-Compliant E-Signatures
for Healthcare

Zignature signs patient consent forms, HIPAA authorizations, and clinical documents securely — with a Business Associate Agreement (BAA) included on all paid plans.

Free plan available · No credit card required · ESIGN Act compliant

BAA
Included on paid plans
HIPAA
Fully compliant
256-bit
AES encryption at rest
21 CFR
Part 11 supported
Built for Healthcare

Compliance Without Compromise

Every Zignature feature is designed to meet HIPAA, state privacy law, and Joint Commission documentation standards.

HIPAA Compliance

Business Associate Agreement Included

Every Zignature paid plan includes a signed Business Associate Agreement (BAA) — the formal HIPAA contract that makes Zignature a covered business associate for your PHI. Signing patient documents through Zignature is fully permissible under HIPAA when using a paid plan. No separate legal negotiation required.

  • BAA on all paid plans — covering all PHI processed through Zignature.
  • 256-bit AES encryption — for data at rest and TLS 1.3 in transit.
  • Audit logs — track every access, view, and modification to PHI-containing documents.
BAA on all paid plans
256-bit AES encryption
Audit logs
Included on all plans
Clinical Documents

Every Patient Document, Digitized

Consent forms, HIPAA authorizations, treatment agreements, release of information forms, advance directives, and financial agreements — Zignature handles every document your patients need to sign. AI field detection places signature and initial blocks automatically, reducing setup time from hours to minutes.

  • Patient consent forms — with conditional logic and required-field enforcement.
  • HIPAA Authorization (45 CFR 164.508) — compliant disclosure forms built in.
  • Advance directives & DNR — with identity verification for high-stakes documents.
Patient consent forms
HIPAA Authorization (45 CFR 164.508)
Advance directives & DNR
Included on all plans
Workflow Automation

Integrate with Your EHR & Practice Management

Zignature connects to your existing systems via REST API, Zapier, or direct integration. Automatically trigger consent form requests when new patients are scheduled. Write back signed status to your EHR. Store completed documents in your practice management system automatically — without manual uploading.

  • REST API — for custom integrations with any EHR or practice management system.
  • Zapier & Make — connect to 3,000+ apps without writing code.
  • Webhook events — trigger EHR updates the moment a patient signs.
REST API
Zapier & Make
Webhook events
Included on all plans
Clinical Use Cases

Every Healthcare Signature Moment

Zignature handles clinical, administrative, and research documentation workflows.

Patient Consent Forms

Collect informed consent before procedures. Patients sign from any device — at home before their appointment or on a tablet in the waiting room.

HIPAA Authorizations

PHI release authorizations that satisfy 45 CFR §164.508 requirements, with required-field enforcement and auto-expiry.

Treatment Agreements

Financial agreements, payment plans, and out-of-pocket cost acknowledgments signed before treatment begins.

Staff & Vendor Agreements

Employee onboarding, BAAs with vendors, HIPAA workforce training acknowledgments — all in one platform.

Telemedicine Consent

Telehealth-specific consent forms with jurisdiction disclosures, signed before every remote visit.

Clinical Trial Documents

Informed consent for research with 21 CFR Part 11 compliant electronic signatures for regulated studies.

How It Works

Up and Running in Minutes

No training required. Send your first document today.

1

Choose Your Template

Pick from pre-built compliant templates or upload your own document — our system applies the right compliance rules automatically.

2

Configure Compliance Settings

Enable HIPAA BAA, GDPR DPA, identity verification, or QES as required for your regulatory environment.

3

Send to Signers

Recipients get a secure link and are guided through the signing process with all required disclosures and consent flows.

4

Archive with Full Audit Trail

Every transaction is sealed with a tamper-proof certificate of completion — ready for audits, regulators, and legal proceedings.

What Does HIPAA-Compliant E-Signature Actually Mean?

HIPAA doesn't ban electronic signatures — it requires that any vendor handling Protected Health Information (PHI) sign a Business Associate Agreement (BAA) and implement appropriate administrative, physical, and technical safeguards. Zignature meets all three categories.

Administrative safeguards: Zignature maintains a formal security program, employee training, and incident response procedures documented in our HIPAA Security Rule policies.

Physical safeguards: All infrastructure runs in SOC 2 Type II certified data centers with 24/7 physical access controls, surveillance, and environmental monitoring.

Technical safeguards: 256-bit AES encryption at rest, TLS 1.3 in transit, role-based access controls, session timeouts, and comprehensive audit logs that record every access to PHI-containing documents.

HIPAA Minimum Necessary Standard and E-Signatures

Under the HIPAA minimum necessary standard (45 CFR §164.502(b)), covered entities must limit PHI access to what's needed for a specific purpose. Zignature's role-based access controls and field-level permissions let you ensure signers see only the information required to complete their specific signature — no more.

For consent forms with sensitive PHI (mental health, substance use, HIV status), Zignature supports enhanced confidentiality settings that restrict sharing and prevent accidental disclosure.

Sign Your First Patient Document Today

HIPAA-compliant e-signatures with BAA included. Trusted by healthcare organizations nationwide.

Frequently Asked Questions

Everything you need to know.

Is Zignature HIPAA compliant for patient signatures?

Yes. Zignature is HIPAA compliant and provides a signed Business Associate Agreement (BAA) on all paid plans. The platform uses 256-bit AES encryption, comprehensive audit logs, and role-based access controls that satisfy HIPAA Security Rule requirements for electronic PHI.

Does Zignature include a Business Associate Agreement (BAA)?

Yes. All paid Zignature plans include a standard BAA that covers PHI processed through the platform. Enterprise customers can request a custom-negotiated BAA. The BAA is available for download from your account settings after upgrading to a paid plan.

Can patients sign consent forms from their phone?

Yes. Patients receive a signing link via email or SMS and can sign from any smartphone, tablet, or computer without creating an account. The mobile signing experience is optimized for touchscreen use, including drawing a signature with a finger.

Is Zignature compliant with 21 CFR Part 11 for clinical trials?

Yes. Zignature supports 21 CFR Part 11 compliant electronic signatures including unique user authentication, closed and open system controls, complete audit trails, and electronic records that meet FDA requirements for regulated clinical trial documentation.

How long are patient documents stored under HIPAA?

Zignature stores documents indefinitely by default. Healthcare organizations typically configure a 6-year retention policy to meet HIPAA's minimum medical records retention requirement (45 CFR §164.530(j)). Enterprise plans support automated retention schedules and legal hold capabilities.

Can Zignature integrate with Epic, Cerner, or Athena Health?

Zignature connects to any EHR or practice management system via REST API, FHIR-compatible webhooks, or Zapier. Native connectors for Epic and Cerner are available for enterprise customers. The API supports automated patient document sending triggered by appointment scheduling or registration events.

What happens to PHI when a document is deleted?

When a document is deleted, all associated PHI is removed from active storage and flagged for secure deletion in accordance with NIST SP 800-88 guidelines. Zignature's data deletion policy is documented in the BAA and available on request.

Does Zignature support identity verification for high-stakes clinical documents?

Yes. Zignature integrates with Stripe Identity for government ID verification and liveness check — useful for advance directives, high-value treatment authorizations, and any document requiring identity assurance beyond standard email authentication.

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